Korean J Intern Med 2016;31:535-542


 

Association between blood glucose level derived using

the oral glucose tolerance test and glycated

hemoglobin level

Hyoung Joo Kim1, Young Geon Kim1, Jin Soo Park1, Young Hwan Ahn1, Kyoung Hwa Ha2,3,
and Dae Jung Kim2,3


 

Abstract

Background/Aims: Glycated hemoglobin (HbA1c) is widely used as a marker of glycemic control. Translation of the HbA1c level to an average blood glucose level is useful because the latter figure is easily understood by patients. We studied the association between blood glucose levels revealed by the oral glucose tolerance
test (OGTT) and HbA1c levels in a Korean population.

Methods: A total of 1,000 subjects aged 30 to 64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort were included. Fasting glucose levels, post-load glucose levels at 30, 60, and 120 minutes into the OGTT, and HbA1c levels were measured.

Results: Linear regression of HbA1c with mean blood glucose levels derived using the OGTT revealed a significant correlation between these measures (predicted mean glucose [mg/dL] = 49.4 × HbA1c [%] − 149.6; R2 = 0.54, p < 0.001). Our linear regression equation was quite different from that of the Alc-Derived Average Glucose (ADAG) study and Diabetes Control and Complications Trial (DCCT) cohort.

Conclusions: Discrepancies between our results and those of the ADAG study and DCCT cohort may be attributable to differences in the test methods used and the extent of insulin secretion. More studies are needed to evaluate the association between HbA1c and self monitoring blood glucose levels.

Keywords: Diabetes mellitus; Hemoglobin A, glycosylated; Oral glucose tolerance test; Mean blood glucose level